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Cura prolongada puede aumentar riesgo de cancer de mamá, hiperlasia endometrial, ataque cardíaco,o paroximo, control de la condición de paciente tiene que ser realizada en base regular.Esta medecina puede tener carácter dañoso al niño no alumbrado,no lo use durante embarazo.No se puede usar Premarin para prevenir enfermedad de corazón o demencia.Para evitar hiperlasia endometrial a Usted pueden prescribir tomar progestágenao junto con Prematin. No se puede usar esta medicina si Usted no tiene 18 años.
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Premarin es una mixtura de hormonas de esrtógeno que regula desarrollo y función de sistema femenina de reproducción, formación de las caracteristicas secundarias sexuales femeninas. Al entrar en sistema circulatorio él forma un complejo con receptor específico ( en los trompas de Falopio, cuello uterino, conducto excretor de glándulas mamarias, vagina, uretra, pecho, hígado, hipotalamus, hipofisis), estimula síntesis de DNA y proteinas. Este resulte en proliferación de epitelio, aumenta sensibilidad de útero y musculas de trompas a las medicinas que estimulan su motilidad. Esta medicina baja la resorción ósea de Ca2+ en menopausa, previene involución de genitalia. Premarin se usa para curar síntomas de menopausa que incluyen sequedad vaginal, sofoco, irritación o sequedad vaginal, para prevenir osteoporosis a los mujeres con postmenopausa. La terapia de sustitucón en los mujeras com peri- y post menopausa, hipofunción ovaria ( amenorrea primaria y secundaria, oligomenorrea, dismenorrea) y otras condiciones.
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